Brighton & Hove Albion will be without Tariq Lamptey as he struggles with an ongoing hamstring issue.
Adam Lallana was substituted at West Ham with a groin injury and is being assessed, along with Aaron Connolly.
Arsenal youngsters Emile Smith Rowe and Gabriel Martinelli could make their second starts of the season after impressing on Boxing Day.
Thomas Partey remains sidelined, while Gabriel is self-isolating due to coronavirus tracing. David Luiz and Willian missed the Chelsea game through illness but have tested negative for Covid-19.
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Burnley are hopeful Dwight McNeil and Robbie Brady will be available after they missed Sunday's defeat at Leeds.
Matej Vydra, Jack Cork and Johann Berg Gudmundsson are back in training but Clarets boss Sean Dyche has intimated the game will come too soon for them.
Sheffield United are assessing Oliver Burke and Oli McBurnie with respective back and shoulder issues.
John Lundstram remains suspended and joins fellow midfielder Sander Berge as certain absentees.
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Southampton will be without defender Jannik Vestergaard for at least four weeks with a knee injury but Oriol Romeu is back from his one-match suspension which ruled him out of the 0-0 draw at Fulham.
West Ham may make changes after manager David Moyes admitted he got his team selection wrong against Brighton & Hove Albion on Sunday.
Forward Michail Antonio has returned to training following a hamstring problem.
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West Brom Albion midfielder Jake Livermore is serving the second game of a three-match suspension.
Meanwhile, Hal Robson-Kanu, Kyle Bartley and Conor Townsend are also all out with injury.
As for the visitors, Leeds defender Liam Cooper is set to miss out due to an abdominal strain as they continue to have central defensive issues after Diego Llorente suffered a setback in training following a recent muscle strain. Robin Koch is a long-term absentee.
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Manchester United will assess the fitness of Marcus Rashford, who sustained a shoulder injury in the draw at Leicester City on Boxing Day.
Daniel James picked up a knock at the King Power Stadium, while Aaron Wan-Bissaka and Victor Lindelof remain out.
Wolves have no new injury concerns for the trip to Old Trafford, with some rotation expected.
Raul Jimenez, Willy Boly, Leander Dendoncker and Jonny are still unavailable.
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